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When tirzepatide produces significant weight loss, often 15 to 20% of body weight over 72 weeks, your levothyroxine requirement naturally decreases
Over time, consistent use combined with lifestyle changes can lead to what some call metabolic flexibilitythe bodys ability to efficiently switch between burning carbs and burning fat for fuel
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[7] In STEP-4 (N=803), participants who continued semaglutide after a 20-week run-in maintained or further reduced their weight, while those who switched to placebo regained 6.9 percentage points of body weight by week 68
Grossini E, De Marchi F, Venkatesan S, et al
10.1152/ajpendo.00109.2014 20 DeVoreA
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